PEG 300


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PEG 300 is a polyethylene glycol with a mean molecular weight of 300. It is a clear, viscous hygroscopic liquid.


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·        Good solubility in water

·        Very low water content

·        Compatible with hard water

·        Non-volatile

·        Outstanding toxicological safety

·        Good biodegradability



PEG are non-toxic and physiologically safe so no special safety precautions need to be taken when handling them. For many applications, particularly in pharmaceuticals, cosmetics and foodstuffs packging, the physiological safety of PEG is important. When administered orally and cutaneously they are to be rated as non-toxic. The vapour pressure of PEG is so low that inhalation of relevant amounts is impossible. Because of their good physiological tolerability PEG were first included in the US pharmacopoeia already in 1950. Since then they have been listed in numerous pharmacopoeias. The tolerability of PEG in animals improves as the degree of polymerization rises. PEG have no toxic or irritant effect on the skin. Because of low toxicity it was not possible to establish an exact LD50 resulting from skin penetration.

Ecological Data

The behaviour of PEG in effluent is a matter of crucial importance, e.g. in their industrial use in the textile sector and in metal processing. The rate of biodegradation of PEG decreases with increasing molar mass. PEG up to molar mass 1500 are regarded as readily biodegradable. The microbiological degradation of other substances is not inhibited by the presence of PEG. The toxic inhibition limit for bacteria in the fermentation tube test is 5000 mg/l. Investigations within our own labs have shown that even in concentrations of 10000 mg/kg (1%) polyethylene glycols have no adverse effect on fish. Polyethylene glycols in concentration up to 10000 mg/l exhibit no harmful effect of any kind towards daphnia and protozoa.

Waste Disposal

Any PEG to be disposed of waste can be taken, in accordance with the local regulations, to a special waste incineration plant. None of PEG, in concentrations up to 10,000 mg/l water, demonstrates an acute harmful effect on fish or bacteria. PEG with molar masses of 200 to 1500 have good biodegradability. It is therefore possible to take them to a biological sewage treatment plant after consulting the operator provided the water and waste regulations permit.

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Appearance at 25 °C

Clear colourless liquid

Colour at 25 °C, APHA

Max. 10

Molecular Mass [g/mol]


OH Value [mg kOH/g]


Solidification Point [°C]

-15- -10

Viscosity at 25°C [cP]


pH 5% aqueous solution


Water Content

Max. 2

Density at 25°C [g/cm³]


Solubility in Water at 20°C


PEG 300 can be used in liquid pharmaceutical preparations such as drops or fillings for gelatin capsules. It can also be used in ointment mixtures for example in combination with Polyglycol 1500.

PEG 300 is listed as active ingredient in ophthalmic demulcents.

It is also used in toothpastes where it improves consistency and storage stability. It acts as a moisturizer in antiperspirants, shampoos and liquid soaps, hair styling products and bar soap.

PEG 300 can also be used in bath oils and foam baths to assist the solubilizing action of the active substances for perfume oils.

It is used as a humectant in waterborne pigment preparations, and as a solvent and humectant in automatic dish-washing products.